Dimethyl Sulfoxide
Apexbio Technology LLC RO5126766(CH5126766) 946128-88-7 10mM (in 1mL DMSO)
RO5126766 (CH5126766 CAS 946128-88-7) is a dual Raf/MEK inhibitor that targets the RAS/RAF/MEK/ERK signaling pathway involved in cellular proliferation survival and differentiation By inhibiting RAF-dependent MEK1 phosphorylation and subsequent MEK-mediated ERK activation RO5126766 suppresses downstream signaling In vitro kinase assays show IC50 values of 0 0082 0 056 M for MEK1 phosphorylation and 0 16 M for MEK1-induced ERK2 activation Studies in KRAS-mutant cancer cell lines such as HCT116 and NCI-H460 demonstrate that RO5126766 blocks MEK and ERK phosphorylation effectively inducing cell cycle arrest at the G1 stage Thus RO5126766 serves as a valuable research tool for investigating tumor biology driven by MAPK signaling dysregulation
Apexbio Technology LLC N6-methyladenosine (m6A) 1867-73-8 10mM (in 1mL DMSO)
N6-methyladenosine (m6A) is a purine derivative functioning primarily as an adenosine receptor agonist and modulates adenylate cyclase activity with reported ED50 approximately 17 25 M It is a common internal modification in eukaryotic messenger RNAs predominantly occurring within consensus motif RRACH (R G or A H A C or U) and affecting RNA stability processing and translation Experimental studies indicate m6A application in cellular models such as murine erythroleukemia (MEL) cells reduces -globin mRNA accumulation thereby suppressing erythroid differentiation initiation Due to its epigenetic regulatory role m6A serves as a tool for studying RNA methylation-dependent gene expression and cellular differentiation
Apexbio Technology LLC Tasquinimod 254964-60-8 10mM (in 1mL DMSO)
Tasquinimod (CAS 254964-60-8) is an orally bioavailable quinoline-3-carboxamide compound with antiangiogenic and antitumor properties It modulates angiogenesis primarily through dual inhibition of S100A9/TLR4 signaling in myeloid-derived suppressor cells (MDSCs) and downregulation of HIF-1 and VEGF expression in tumor and endothelial cells It also enhances thrombospondin-1 (TSP-1) expression further suppressing neovascularization Preclinical studies in human prostate cancer xenograft models indicate significant antineoplastic activity particularly in combination with docetaxel radiation therapy or androgen-depletion strategies suggesting its therapeutic potential for castration-resistant prostate cancer (CRPC)
Apexbio Technology LLC PF-4708671 1255517-76-0 10mM (in 1mL DMSO)
PF-4708671 (CAS 1255517-76-0) is a cell-permeable small molecule that specifically inhibits p70 ribosomal S6 kinase 1 (S6K1) S6K1 regulates diverse cellular processes including protein synthesis and insulin signaling pathways PF-4708671 inhibits S6K1 with an IC50 of 160 nM in HEK293 cell-derived enzyme assays and has a reported Ki value of 20 nM in vitro It selectively inhibits S6K1 over structurally related kinases such as RSK2 and MSK1 hindering phosphorylation of downstream substrates including ribosomal protein S6 mTOR and Rictor PF-4708671 is valuable in biomedical research involving cancer and insulin resistance
Apexbio Technology LLC TAE226 (NVP-TAE226) 761437-28-9 10mM (in 1mL DMSO)
TAE226 (NVP-TAE226 CAS 761437-28-9) is a selective inhibitor targeting focal adhesion kinase (FAK) with an IC50 of 5 5 nM and it also inhibits the related protein tyrosine kinase Pyk2 (IC50 3 5 nM) By suppressing FAK activity crucial for cell adhesion and migration TAE226 influences cellular processes associated with tumor progression Studies using glioma cells (including U87 and variants) and medullary thyroid carcinoma line MZ-CRC-1 revealed that TAE226 decreases cell proliferation invasion and induces apoptosis highlighting its potential value in cancer research
Apexbio Technology LLC Cefoperazone 62893-19-0 10mM (in 1mL DMSO)
Cefoperazone is a third-generation cephalosporin antibiotic with broad-spectrum antibacterial activity widely applied in biomedical research focused on transport-related mechanisms It exhibits inhibitory effects on rMrp2-mediated transport of [ 3H]estradiol-17 -glucuronide ([ 3H]E217 G) with a reported IC50 value of approximately 199 M Importantly the inhibitory profile of cefoperazone displays biphasic characteristics suggesting distinct binding sites the obtained IC50 values are 6 66 3 23 M (high-affinity component) and 3 88 1 32 mM (low-affinity component) These properties facilitate its use as a probe compound to assess transport pathways in pharmacokinetic and drug disposition studies
Apexbio Technology LLC 17-AAG (KOS953) 75747-14-7 10mM (in 1mL DMSO)
17-AAG (KOS953) is a synthetic derivative of geldanamycin that inhibits heat shock protein 90 (HSP90) It acts by binding to HSP90 causing destabilization of client proteins including HER2 Raf-1 p53 and components of MAPK signaling pathways Reported IC50 for 17-AAG in BT474 cells is approximately 6 nM Its biological activity has been investigated broadly including in multiple myeloma breast cancer thyroid cancer Hodgkin lymphoma and melanoma cellular models Ongoing studies explore 17-AAG both as monotherapy and in combination with agents like bortezomib or trastuzumab for addressing treatment-resistant cancer cell lines Currently 17-AAG is evaluated in Phase II clinical trials
TARGETMOL CHEMICALS INC TRAMETINIB DMSO SOLVATE 200MG
Also available in 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Trametinib (DMSO solvate) (GSK-1120212 (DMSO solvate)) is a Highly Potent and Selective MEK Inhibitor that specifically inhibits MEK1/2(IC50 2 nM)purity: 99%
Apexbio Technology LLC Tetrahydrozoline HCl 522-48-5 10mM (in 1mL DMSO)
Tetrahydrozoline HCl (CAS 522-48-5) is an imidazoline-based small molecule that functions primarily as an agonist at alpha-adrenergic receptors Activation of these receptors by tetrahydrozoline elicits vasoconstriction via smooth muscle contraction reducing redness and swelling Due to this mechanism tetrahydrozoline hydrochloride is commonly utilized as a research tool to investigate alpha receptor-mediated physiological and pharmacological responses particularly in cardiovascular and ocular experimental models
Apexbio Technology LLC Stattic 19983-44-9 10mM (in 1mL DMSO)
Stattic (CAS 19983-44-9) is a small-molecule inhibitor specifically targeting signal transducer and activator of transcription 3 (STAT3) It suppresses STAT3 activation by blocking its dimerization nuclear translocation and subsequent transcriptional activity In vitro studies demonstrate Stattic inhibits proliferation in multiple head and neck squamous cell carcinoma (HNSCC) cell lines including UM-SCC-17B OSC-19 Cal33 and UM-SCC-22B with reported IC50 values ranging from approximately 2 3 to 3 5 M Additionally Stattic downregulates STAT3-mediated hypoxia-inducible factor-1 (HIF-1) expression resulting in enhanced radiosensitivity in HNSCC cells and shows activity in mouse xenograft tumor models Therefore Stattic serves as a research tool for investigating STAT3-associated signaling pathways and cancer biology
Apexbio Technology LLC YO-01027 (Dibenzazepine, DBZ) 209984-56-5 10mM (in 1mL DMSO)
YO-01027 (Dibenzazepine DBZ CAS 209984-56-5) is a potent inhibitor targeting -secretase a multimeric aspartyl protease involved in the proteolytic cleavage of type I integral membrane proteins notably amyloid precursor protein-like (APPL) proteins and Notch receptors YO-01027 interacts with the N-terminal regions of presenilin dose-dependently inhibiting cleavage of APPL and Notch proteins Research indicates that YO-01027 modulates cell differentiation by suppressing Notch signaling pathways influencing cellular transitions and mucin (MUC16) synthesis illustrating its utility in cell biology and therapeutic studies of Notch-related signaling processes