Dimethyl Sulfoxide
Apexbio Technology LLC Apatinib 10mM (in 1mL DMSO)
B2303 is a synthetic small molecule designed for biomedical research acting primarily as an inhibitor targeting specific intracellular signaling pathways involved in cell proliferation and survival It modulates intracellular signaling cascades implicated in pathological conditions such as inflammation cancer progression and aberrant cell growth B2303 serves as a molecular probe suitable for investigating intracellular processes and as a tool for dissecting signal transduction mechanisms enabling researchers to explore therapeutic targets for various diseases
Apexbio Technology LLC Methazolamide 554-57-4 10mM (in 1mL DMSO)
Methazolamide (CAS 554-57-4) is a sulfonamide-derived inhibitor of carbonic anhydrase (CA) selectively targeting isoforms CAII and CAIV with IC50 values of 8 1 nM and 80 3 nM respectively By suppressing CA activity methazolamide reduces bicarbonate ion production thus decreasing fluid secretion and intraocular pressure consequently it has clinical use in glaucoma management Recent studies indicate this compound also exhibits insulin-sensitizing properties distinct from other CA inhibitors notably reducing hepatic glucose output suggesting potential applications in diabetes research and metabolic disorders
Apexbio Technology LLC Radezolid 869884-78-6 10mM (in 1mL DMSO)
Radezolid is an oxazolidinone-class antibiotic under investigation targeting Gram-positive bacterial pathogens including methicillin-resistant Staphylococcus aureus (MRSA) By accumulating intracellularly within various host cells such as macrophages epithelial cells and endothelial cells Radezolid disrupts bacterial protein synthesis through inhibition of bacterial ribosomal translation In vitro assessments show antibacterial potency approximately tenfold greater than Linezolid at identical concentrations in infected cell models MIC90 values for MRSA strains indicate enhanced potency relative to Linezolid with MIC90 at approximately 0 5 mg/l compared to 2 0 mg/l for Linezolid Experimental animal models display increased Radezolid accumulation in infected tissues (2 4-fold higher tissue AUC compared to non-infected counterparts) Radezolid is explored in research settings examining complicated skin infections and community-acquired pneumonia (CAP)
Apexbio Technology LLC SGX-523 1022150-57-7 10mM (in 1mL DMSO)
SGX-523 (CAS 1022150-57-7) is an ATP-competitive selective inhibitor targeting the receptor tyrosine kinase c-Met (hepatocyte growth factor receptor) It effectively blocks c-Met autophosphorylation in gastric carcinoma cell line GTL16 (IC50 40 nM) and human lung cancer cell line A549 (IC50 12 nM) In vivo studies demonstrate tumor regression upon oral administration of SGX-523 in mouse xenograft models of GTL16 and human GBM cell line U87MG Moreover it inhibits phosphorylation of MEK MAPK and Akt pathways reducing proliferation migration invasion and cell cycle progression in glioma cell models SGX-523 serves as an important research tool for oncology studies involving c-Met signaling
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide puriss500ML
Dimethyl sulfoxide (DMSO) is a polar solvent. DMSO activated by electrophile (oxalyl chloride) has been used to oxidize various alcohols (primary secondary allylic benzylic hindered and bicyclic). Carbonyl compounds are formed as reaction products. It has been proposed as an alternate solvent for methyl cellosolve for use in ninhydrin reaction due to its high stability.
Apexbio Technology LLC Bendamustine HCl 3543-75-7 10mM (in 1mL DMSO)
Bendamustine HCl (CAS 3543-75-7) is an alkylating agent that induces cytotoxicity primarily through DNA damage Mechanistically it disrupts the mitotic checkpoint by downregulating key regulators such as polo-like kinase 1 Aurora kinase A and cyclin B1 leading to mitotic failure and subsequent apoptosis In myeloma models bendamustine activates apoptosis signaling that involves ATM-mediated G2 cell cycle arrest cleavage of caspase-3 and mitochondrial apoptotic pathways It demonstrates dose-dependent antiproliferative activity in dexamethasone-sensitive (MM1 S IC50 119 8 M) and resistant (MM1 R IC50 138 M) multiple myeloma cell lines Bendamustine represents a useful research tool for studying DNA damage response and apoptosis in hematological malignancy contexts
Apexbio Technology LLC Santacruzamate A (CAY10683) 1477949-42-0 10mM (in 1mL DMSO)
Santacruzamate A (CAY10683 CAS 1477949-42-0) is a selective histone deacetylase (HDAC) inhibitor originally identified in the marine cyanobacterium cf Symploca sp Its mechanism of action involves targeting HDAC enzymes particularly demonstrating high selectivity towards HDAC2 (IC 0 112 nM) when compared with HDAC6 (IC 433 nM) and minimal potency against HDAC4 (IC 1 M) In cellular assays Santacruzamate A reduces growth of tumor cell lines such as HCT-116 colon cancer cells (GI 28 M) and HuT-78 cutaneous T-cell lymphoma cells (GI 1 3 M) It is valuable in epigenetics and oncology research for selectively modulating HDAC2 activity
Apexbio Technology LLC Parthenolide 20554-84-1 10mM (in 1mL DMSO)
Parthenolide (CAS 20554-84-1) is a sesquiterpene lactone naturally derived from feverfew (Chrysanthemum parthenium) It exerts biological activity primarily via inhibition of the NF- B signaling pathway suppression of STAT3 activation and modulation of oxidative stress pathways leading to anti-inflammatory and anticancer effects In biomedical research parthenolide is commonly utilized to investigate molecular mechanisms governing inflammation cellular apoptosis and tumor growth suppression as well as in studies targeting leukemia and solid tumors
Apexbio Technology LLC Dronedarone 141626-36-0 10mM (in 1mL DMSO)
Dronedarone (CAS 141626-36-0) is a benzofuran derivative structurally related to amiodarone designed to manage cardiac arrhythmias It exerts its pharmacological effects primarily through multichannel blockade inhibiting sodium potassium and calcium ion currents and demonstrating anti-adrenergic properties By prolonging action potential duration and refractory periods dronedarone contributes to the stabilization and restoration of regular cardiac rhythm In biomedical research contexts dronedarone serves as a valuable tool for exploring arrhythmogenesis mechanisms and developing therapeutic approaches for atrial fibrillation and atrial flutter
Apexbio Technology LLC Vildagliptin (LAF-237) 274901-16-5 10mM (in 1mL DMSO)
Vildagliptin (LAF-237 CAS 274901-16-5) is an inhibitor of dipeptidyl peptidase-4 (DPP-4) a widely expressed antigenic enzyme with roles in signal transduction apoptosis and immunoregulation Vildagliptin inhibits DPP-4 enzymatic activity at an IC50 of approximately 2 3 nM preventing the degradation of glucagon-like peptide-1 (GLP-1) Through enhanced GLP-1 activity it promotes insulin secretion and reduces glucagon release Animal model studies including experiments in obese Zucker rats demonstrated improved glucose tolerance increased beta-cell proliferation decreased apoptosis and neuroprotective effects Vildagliptin is thus relevant for diabetes mellitus type 2 and related biomedical research
Apexbio Technology LLC HATU 148893-10-1 10mM (in 1mL DMSO)
HATU (1-[Bis(dimethylamino)methylene]-1H-1 2 3-triazolo[4 5-b]pyridinium 3-oxid hexafluorophosphate) is a peptide coupling reagent routinely employed for amide-bond formation in peptide synthesis and other biomolecular applications In solution HATU converts carboxylic acids into active ester intermediates (OAt esters) facilitating subsequent nucleophilic attack from amines or alcohols This reaction typically proceeds in presence of basic additives such as N N-Diisopropylethylamine (DIPEA) under anhydrous conditions in solvents like dimethylformamide (DMF) Its utility extends to synthesizing peptides and modifying biomolecules through ester or amide linkage formation widely applied in biomedical research and pharmaceutical laboratories
Apexbio Technology LLC PF-3758309 898044-15-0 10mM (in 1mL DMSO)
PF-3758309 (CAS 898044-15-0) is a selective ATP-competitive inhibitor of p21-activated kinase 4 (PAK4) a serine/threonine kinase involved in cytoskeletal reorganization and cellular signaling mediated by Cdc42-GTP and JNK-GTP interactions PF-3758309 inhibits phosphorylation of PAK4 substrates (e g GEF-H1 IC50 1 3 nM) and suppresses PAK4-mediated anchorage-independent growth In xenograft tumor models (HCT116 A549) oral administration of PF-3758309 significantly reduced tumor growth demonstrating its utility in research investigating PAK-dependent oncogenic pathways
Apexbio Technology LLC ITF2357 (Givinostat) 732302-99-7 10mM (in 1mL DMSO)
ITF2357 (Givinostat CAS 732302-99-7) is a small molecule inhibitor targeting class I and II histone deacetylases (HDAC) It suppresses hematopoietic colony formation driven by JAK2V617F mutation in chronic myeloproliferative neoplasms Mechanistically ITF2357 induces apoptosis in multiple myeloma (MM) and acute myeloid leukemia (AML) by elevating p21 expression and simultaneously reducing anti-apoptotic proteins Bcl-2 and Mcl-1 Additionally ITF2357 diminishes inflammatory cytokines (IL-1 IL-6 TNF- and IFN- ) in peripheral blood mononuclear cells and inhibits production of IL-6 and VEGF in mesenchymal stromal cells reflecting potential therapeutic applications in cancer research and inflammation regulation
Apexbio Technology LLC Reversine 656820-32-5 10mM (in 1mL DMSO)
Reversine (CAS 656820-32-5) is a small molecule inhibitor targeting Aurora kinases a family of serine/threonine kinases involved in mitotic progression Reversine inhibits Aurora kinase A B and C with IC50 values of 150 nM 500 nM and 400 nM respectively In vitro studies show reversine can induce dedifferentiation of murine myoblast cells and possesses regenerative potential Additionally reversine displays anti-tumor effects by suppressing the expression of Aurora kinases thus disrupting cell-cycle progression In cervical carcinoma mouse models (U14 cells) reversine combined with aspirin synergistically decreases tumor growth highlighting reversine s value for cancer biology research